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External Collaboration

Various collaborative activities with individuals outside the company

Advances are made daily in safety research. To be able to conduct evaluations in the most appropriate way, it is essential to acquire the most-up-to-date technologies and information and to share Shiseido's technologies with experts. That is, researchers in safety assurance at Shiseido have been working with outside experts in a wide range of activities. Some of those activities are described below.

・Interactions with outside experts

・Industry activities

・Development of professional human resources

・Basic research on safety

Shiseido’s commitment on alternatives to animal experiments

・Sharing of research findings

Shiseido shares findings obtained from years of research not only on this website, but also through contributing to academic literature and participating in conferences. We strongly hope that due to such efforts, alternative testing methods developed by Shiseido become widely used by a greater number of research institutions, and will continue to improve.

・Further research on alternative methods

Shiseido continues to proceed with its research on alternative testing methods with an aim to further improve measurement accuracy regarding the use of ingredients, and expand the scope of testing while challenging itself to develop alternative in vitro/in silico testing methods for assessing systemic toxicity.

・Efforts on establishing officially acceptable methods and industry standards

<Research commended by specialized academic societies, etc>

Year Shiseido’s studies that have contributed to the development of alternative methods and safety evaluation
2018 ・In silico risk assessment for skin sensitization using artificial neural network analysis
2016

・Safety assessment of Cosmetic Ingredients by Hand1-Luciferase Embryonic Stem cell Tests

・Application of photo-KeratinoSens to Integrated Testing Strategy of photosensitization

・In silico risk assessment for human percutaneous absorption and skin sensitization of drug

・In silico risk assessment for skin sensitization using artificial neural network analysis

2015 ・Specificity evaluation of Embryonic Stem cell Test for cosmetic ingredients
2014 ・Development of h-CLAT, an alternative to skin sensitization test
(jointly awarded the JCIA Special Award in Technology with Kao Corporation)
2011 ・Study on cell-surface SH groups as a marker in an alternative skin sensitization test (SH test)
2008 ・Study on an eye irritation evaluation method based on a combination of SIRC-CVS test and the three-dimensional cultured skin model test
2005

・Joint study in Japan on the in vitro skin sensitization test: h-CLAT (human Cell Line Activation Test)

・Study on the effect of light in in vitro phototoxicity tests

2003 ・Study on alternative methods of acute toxicity testing using cultured cells
2002 ・Study on the development of a formula for predicting percutaneous absorption and its application in predicting sensitization potentials
2001 ・Study on an in vitro sensitization test that measures the expression of CD86 and MHC class II as markers in the THP-1 human monocytic cell line
2000 ・Study on the induction of unscheduled DNA synthesis in the epidermis by skin carcinogens
1999 ・Study on cell line differences in photocytotoxicity tests
1997 ・Study on the use of the cytotoxicity test of poorly soluble substances as an alternative method for skin irritation testing
1996 ・Study on the use of quantitative measurement of pro-inflammatory cytokine gene expression as an alternative method for skin irritation testing
1994 ・Study on the application of electrophysiological techniques and other techniques on neuronal cells for use as an in vitro sensory irritation test
1992 ・Study on in vitro phototoxicity tests with red blood cells and yeasts
1991

・Study on an in vitro test of eye irritation using hemoglobin as a biomarker

・Study on the use of liposomes prepared from lipids extracts of the cornea as an alternative for eye irritation testing