Backed by world-leading skin research, SHISEIDO’s iconic ULTIMUNE is a serum reborn—to slow the skin aging cycle.

March, 2025 – Shiseido Company, Limited (“Shiseido”), creator of luxury skincare brand SHISEIDO, announces its latest science-backed innovation: a new ULTIMUNE, backed by over 30 years of research, and infused with SHISEIDO’s own world-leading technology focused on skin’s innate strength for fundamental aging care. Infused with new patented*² technology of Power Fermented Camellia+, ULTIMUNE ignites skin’s regeneration power*³, to infuse 30 million skin cells*⁴ with new life. Slow the skin aging cycle*¹ and see the clinically proven results: visibly reduced aging signs.
*¹the negative spiral leading to fine lines and wrinkles from dryness
*²JP7579470B2 　
*³Skin regeneration power is recovering the skin's ability to maintain its moisture barrier.
*⁴stratum corneum on surface

Beyond just strengthening skin’s barrier, ULTIMUNE produced remarkable results in both clinical tests and consumer tests prove that it slows the skin aging cycle by reducing aging factors*¹. And 98% felt that aging signs*² were visibly reduced in 4weeks*³.
*¹The negative spiral leading to fine lines and wrinkles from dryness　
*²dryness and wrinkles.　
*³Consumer test result of 107 women.

ULTIMUNE Power Infusing Serum（50mL）

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【Product List】

ULTIMUNE Power Infusing Serum＜Serum＞ 30mL/50mL/75mL
ULTIMUNE Power Infusing Serum (Refill)＜Serum＞ 50mL/75mL

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Efficacy results prove skin improvement

-Clinically shown to improve 11 aging signs*¹
-Clinically shown to improve: +51% Radiance, +38% Firmness, +63% Smoothness.*²
*¹Even skin tone, skin transparency, redness, dullness, pores, roughness, firmness, wrinkles, smile lines, elasticity, fine lines
*²*Clinical test on 34 women for 8 week.s

Consumer test results*¹: significant improvements in skin condition

SHISEIDO has identified these qualities as the keys to slow aging skin producing healthy, smooth skin with a natural glow.
-In just 3 days:
98% felt their skin had a healthy glow.
-After 4 weeks:
98% felt the serum slowed the skin aging cycle by reducing aging factors*²
98% felt aging signs*³ were visibly reduced.
97% said their skin looks more youthful.
-After using one bottle*⁴:
99% felt their skin had become resistant to aging signs*³.
98% felt the serum helped their skin deflect aging from the core.
98% felt the serum will help sustain their beauty for 10years.
*¹Based on consumer sensory tests with 107 women
*²The negative spiral leading to fine lines and wrinkles from dryness
*³dryness and wrinkles
*⁴Using 50mL of ULTIMUNE bottle for 8 weeks

Key technology and Ingredients

A concentrated extract of Japanese camellia from Gotoh Island, where camellias bloom vigorously, despite the harsh environment.

The core of our key ingredient: Power Fermented Camellia+ with patented technology*¹
SHISEIDO’s innovative patented technology*¹ of Power Fermented Camellia+ contains Camellia seed extract, with antioxidant properties. Through a fusion of cutting-edge bio-fermentation technologies inspired by traditional Japanese ki-koji fermentation, SHISEIDO now amplifies the potential of amino acid for the skin, boosting the amino acids in camellia seeds by 3.4x*².
Targeting the source of aging in the skin, this unique ingredient supports protecting the skin from aging factors such as dryness and boosts your skin’s innate strength to achieve its full beauty potential.
*¹JP7579470B2
*²Compared to before fermentation


With respect for nature and the ideal of less-waste production, almost every bit of the camellia plant is utilized in new ULTIMUNE.
From petals to leaves to seeds, virtually every bit of the Gotoh Island camellia plant is utilized in making ULTIMUNE. This reflects Shiseido’s focus on sustainability, and concern for the ecosystems of our sourcing locations.
-Camellia Seed Extract : Made by upcycling the strained lees of the camellia seeds, to bring the full power of fermented camellia. Contains Camellia Seed Extract with anti-oxidant properties.
-Camellia Leaf Extract: supports protecting the skin from stimulus of excess sebum due to dryness.
-Camellia Flower Extract: supports the skin barrier by improving the stratum corneum’s resistance.
-Camellia Seed Oil: supports moisture with an emollient effect.