Continued Use for Eight Weeks To Improve Wrinkles

Pure Retinol provides total care, addressing all causal factors in the stratum corneum,
epidermal and dermal skin layers.

• Continued use for eight weeks improves wrinkles
  Pure Retinol has positive effects on wrinkles around the eyes and
  on the neck.

  

  Continued use of a cream containing Pure Retinol results in steady improvement of wrinkles around the eyes.
  The ingredient affects not only the outer skin surface, but the dermal layer of the skin as well. And in addition to wrinkles around the eyes and mouth, it is effective in improving neck wrinkles as well.

• Pure Retinol provides total care that addresses all causal factors in the stratum corneum, epidermal and dermal skin layers, reducing existing wrinkles while mitigating future wrinkle formation.

  

  Pure Retinol is unique in its total-care effects on the stratum corneum, epidermal and dermal skin layers. It is believed to reduce existing wrinkles while mitigating future wrinkle formation.

• Shiseido’s world-first technology has enabled discovery of the “root causes behind wrinkles.”
  When the skin’s stratum corneum layer becomes too hard, it puts a burden on the dermal layer below, leading to wrinkle formation.

  

  Shiseido employed world-first skin analysis technology to discover that, as the skin’s outer (stratum corneum) layer becomes harder with age, the dermal layer underneath becomes softer. This gap of hardness facilitates increased wrinkle formation, and was identified by researchers as the root cause of wrinkles.

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  Furthermore, it was discovered that increased hardness of the skin may lead to increasingly deep wrinkles.

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  The Disparity Between Stratum Corneum and Dermal Layers Drives Wrinkle Formation

  Using proprietary technologies developed in-house, Shiseido researchers revealed that the outer, stratum corneum layer of the skin becomes tougher while the dermal layer underneath simultaneously becomes softer and less taught over time. Continued analysis revealed that manipulation of the skin through forming of facial expressions and other such movements in a person with a toughened stratum corneum layer imparts significant mechanical stress on the dermis underneath, which may result in faster breakdown of collagen within the dermis. In other words, Shiseido researchers made the novel discovery that toughening of the stratum corneum combined with collagen breakdown within the dermis serve as one cause of wrinkle deepening over time. As follows, maintaining a soft and pliable stratum corneum layer can have an improvement effect on wrinkles.

  

• Effects on the Stratum Corneum

  Tests have confirmed that continued use of Pure Retinol for four weeks leads to a softer stratum corneum. Moreover, continued use thereafter increases water content in the stratum corneum layer, boosting softness and pliability.

  

  Continued Use of Pure Retinol Leads to Changes in Stratum Corneum Cell Water Content

  The deeper the blue coloring, the greater the water content in the stratum corneum cells

  

  Effects on the Epidermis

  Tests using epidermal cells (keratinocytes) showed that hyaluronic acid had increased 48 hours after the addition of Pure Retinol. Water content in the epidermal and stratum corneum layers increased, which is expected to increase softness and pliability.

  Pure Retinol Promotes Greater Hyaluronic Acid Production

  

  Epidermal hyaluronic acid quantity evaluations confirmed that Pure Retinol promotes greater production.

  Addition of Pure Retinol Leads to Changes in Hyaluronic Acid Production

  

  Effects on the Dermis

  Tests using dermal cells (fibroblasts) showed that type I collagen amounts had increased 48 hours after the addition of Pure Retinol. This is expected to help skin recover its firmness and elasticity and have an improvement effect on deep wrinkles.

  Pure Retinol Promotes Greater Type I Collagen Production