Photoaging(*) progresses through exposure to UV rays, and this in turn leads to wrinkles, dark spots, sagging, and other skin concerns of adults. Since the 1990s, Shiseido has focused on research of the basement membrane as a means to confront photoaging. As such, it has accumulated vast expertise through the work of numerous researchers in the field.
*Photoaging is the aging of the skin caused by UV rays from the sun, including dark spots, wrinkles, and sagging.
Shiseido has clarified that the basement membrane inside the skin is damaged by UV rays, which also have an adverse effect on epidermal stem cells that generate new cells in the skin. Shiseido has also clarified that skin aging begins from the basement membrane at an earlier stage than aging appears on the surface of the skin.
Damage to the basement membrane occurs where the skin is renewed, as an upstream mechanism, so to speak. Shiseido’s unique ingredient CoreXymide provides fundamental and multi-faceted support for the skin’s natural rejuvenating ability.
Shiseido identified two major enzymes that are activated by UV rays and damage the basement membrane, and searched for ingredients that simultaneously suppress these two enzymes. The number of candidates screened exceeded 20,000. CoreXymide is one achievement of research on the basement membrane that has been passed down by the researchers.
Shunsuke Iriyama,Researcher
Shiseido has researched the basement membrane for more than 30 years. Inheriting the innovative mindsets of their predecessors across generations, many researchers have been involved and made steady progress while coming up against various challenges along the way. I have also joined this research project, and discovered that the
We, researchers, are constantly researching ways to provide solutions to enrich people’s lives through cosmetics. Moving forward, we will continue to evolve our research into the basement membrane while passing down the expertise we have accumulated to the next generation of researchers.
